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乙酰化白藜芦醇

乙酰化白藜芦醇

产品名称:乙酰化白藜芦醇

化 学 名:3,4’,5-三乙酰氧基反式二苯乙烯

产品规格:98%

产品外观:白色或类白色粉末

检测方法:HPLC

分 子 式:C20H18O6

分 子 量:354.35

CAS  号:42206-94-0

产品描述:乙酰化白藜芦醇是天然提取的虎杖白藜芦醇的基础上进行一步化学合成的的衍生产品。乙酰化白藜芦醇进入体内后,在体内转变为白藜芦醇,发挥其生物活性,它相对于白藜芦醇来说具备以下特点:

1.稳定性增强;

2.生物利用度提高 ,由于延长了体内的停留时间,提高了半衰期,生物利用度较好。

产品应用:乙酰化白藜芦醇可广泛应用于食品,饮料及保健品方面。

 

 

 

Production Name: Acetyl-resveratrol

Synonyms: Acetyl trans-resveratrol; 1,3-Benzenediol,5-[(1E)-2-[4-(acetyloxy)phenyl]ethenyl]-, diacetate (9CI); 1,3-Benzenediol,5-[2-[4-(acetyloxy)phenyl]ethenyl]-, diacetate, (E)-; 3,4′,5-Triacetoxy-trans-stilbene; 3,5,4′-Tri-O-acetylresveratrol; Trans-Resveratrol triacetate

Specification: 98%

Appearance: White to off-white powder

Test Method: HPLC

Molecular Formula: C20H18O6

Molecular Weight: 354.35

CAS No: 42206-94-0

Description: Acetyl-resveratrol is called prodrug on medicinal chemistry, it is more stable than trans-resveratrol. When absorbed, it returns to resveratrol under action of metabolism.

The main drawback with current resveratrol forms is the low oral bioavailability. Resveratrol is water-insoluble substance; it can be easily excreted when intaked. This is why finding these acetylated analogs has been so significant; they have better bioavailability and increased biological activity in comparison to the base phenolic compounds. Multiple studies have shown that acetylated analogs of Resveratrol exhibit the same or higher inhibitory effects on various tumor cell lines than Resveratrol itself while being absorbed faster and resisting cellular breakdown. Since the acetylated Resveratrol is being absorbed more quickly, plasma levels in the body reach a higher level and at a faster rate. Through ester hydrolysis enzymes in the body actually break down acetylated Resveratrol back to its natural phenolic form.

Dosage form varied from pill to capsule up to different requirements when use Acetyl-resveratrol as raw material.

Resveratrol is unstable because its Hydroxyls are active group when exposure to oxygen, light and heat. The purpose of acetylation is to inactivate Resveratrol before absorption.

Acetyl-resveratrol is soluble in water (but not resveratrol). Therefore, it can be widely used in cosmetic industry, pharmaceutics, food, beverage, health products.

 

Keywords: Acetyl-resveratrol, Acetyl trans-resveratrol, Trans-Resveratrol triacetate

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